Episode 4: Oxygen Epigenetics

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Episode 4: Oxygen Epigenetics

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Oxygen Epigenetics or O2 EPI; A re-branding of Hyperbaric Oxygen Therapy for the 21st Century and beyond.

Hyperbaric oxygen therapy has been a misunderstood therapy for over 300 years. As a wound care treatment that simply uses oxygen in a pressurized chamber it was clear that HBOT makes wounds heal faster, and that’s it. Many people have benefited from this fact, however it somehow wasn’t enough to gain the attention of the medical community. In fact it was given a bad name – like snake oil.

Welcome to our podcast series where it is our aim to discredit the dogma and bring awareness to the many uses of hyperbaric oxygen therapy. In this episode Dr. Paul Harch talks about the science that he and other Doctors of Emergency Medicine have come to discover after years of dedication to this practice, and the help of advances in technology.

It is here and now that Dr. Harch introduces the re-branding of hyperbaric oxygen therapy by showing us how the healing is attributed to gene therapy. Epigenetics is the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. Under hyperbaric medical conditions it has been found that the healing takes place on the DNA level. “Hyperbaric oxygen through increases in pressure and oxygen are acting at the epigenetic level to express and suppress genes, therefore we should re-brand hyperbaric oxygen therapy for the 21st century as Oxygen Epigenetics or O2 Epi” PGH M.D.

Episode 3: Traumatic Brain Injury Treatment

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Episode 3: Traumatic Brain Injury Treatment

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Visit HBOT.com for more information on TBI Treatment
Brain SPECT scan of a traumatic brain injury before and after Hyperbaric Oxygen Treatment

In this episode Dr. Harch tells us that “hyperbaric oxygen therapy is a treatment for wounds in the body at any location and for any duration.” Doctor Harch talks exclusively about treating wounds in the brain. Treatment for traumatic brain injury is possible using hyperbaric oxygen therapy and Dr. Harch explains in scientific terms how this is done.


The application of hyperbaric oxygen therapy (HBOT) to chronic traumatic brain injury (TBI) can be traced to clinical practice and research in South Florida and New Orleans, Louisiana. It is well known that the practice of HBOT in chronic neurological conditions was pioneered by the late Dr. Richard Neubauer in the 1970s. As mentioned on a previous podcast, Dr. Neubauer began with a unexpected finding of neurological improvement in two multiple sclerosis patients who were being treated with HBOT for chronic bone infections, Dr. Neubauer began applying hyperbaric oxygen to patients with other neurological conditions, primarily stroke. In 1994, he published his first case of HBOT treatment of chronic TBI in the Southern Medical Journal.

For more information visit HBOT in the Treatment of Chronic Traumatic Brain Injury


Episode 2: Hyperbaric Oxygen Effect on the Inflammation Reaction

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Episode 2: Hyperbaric Oxygen Effect on the Inflammation Reaction

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On HBOT-in-Wound Care join Dr. Paul Harch and myself as we create and publish this podcast series to bring awareness of how Hyperbaric Oxygen treatment aids the body’s growth and repair systems. Dr. Harch explains the science behind HBOT and thereby shows us how this is “… the most simple, yet complex and elegant gene therapy known to man-kind.” -PGH M.D.

Hyperbaric Oxygen Physician Dr. Paul Harch continues the HBOT-in-Wound Care podcast series by explaining the inflammation reaction the body has to any injury and the benefits of this treatment.

Episode 2 Show notes

Did you know that every injury to your body causes an inflammation reaction? From a bump on the head to an automobile accident – the body’s damage control system is started, however too much inflammation of “swelling” can cause other problems and sometimes death.

On this episode of HBOT-in-Wound Care Dr. Paul Harch talks about the Hyperbaric oxygen therapy effect on the inflammation reaction in great detail so we can comprehend the science and benefit of HBOT.

Links and Highlights

Polymorphonuclear neutrophils

HBOT Sensible Notion

Hyperbaric Oxygen Therapy is not limited by the science but reimbursement. The science demands that HBOT is beneficial to a much broader selection of conditions then the FDA’s chosen 13.

Episode 1: What is Hyperbaric Oxygen therapy

Welcome to HBOT in Wound Care
Episode 1: What is Hyperbaric Oxygen therapy

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Welcome to the first Harch HBOT podcast. Speaker Paul Harch MD, author of THE OXYGEN REVOLUTION, & Clinical Professor of Medicine, LSU School of Medicine offers this educational experience. Stay tuned for a variety of topics.

What is hyperbaric oxygen therapy? Basically it’s a treatment for wounds in the body at any location and for any duration that uses 100% oxygen as the drug administered under pressure in what’s known as the hyperbaric oxygen chamber.

But what is really happening?

Dr. Harch reviews the traditional definition defined by hyperbaric oxygen doctors and explains the defined pressure setting of 1.4 ATA as too limited. For, in a 2008 study involving U.S. Soldiers suffering a traumatic brain injury and/or post traumatic stress Harch discovers that there is a wider spectrum concerning pressure. As the FDA instructs Dr. Harch to find out and prove what this treatment is, and the combinations of increased oxygen and increased pressure he realizes that HBOT used to stimulate new soft tissue growth and repair is actually connected to specific hormones in our DNA.

Dr. Harch explains the science of hyperbaric oxygen therapy that has recently been realized as gene therapy.


Medical Gas Research Published online 2015 Jul 14
PMCID: PMC4499900
Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy

1. Air or Gas Embolism
2. Carbon Monoxide Poisoning
3. Gas Gangrene
4. Crush injury
5. Decompression Sickness
6. Arterial Insufficiencies
7. Anemia
8. Intracranial Abscess
9. Necrotizing soft tissue infections
10. Osteomyelitis
11. Radiation Injury
12. Thermal burn Injury
13. Idiopathic Sudden Sensorineural Hearing Loss

Thank you Dr. Harch.

If you would like to learn more about HBOT, subscribe to our podcast as we continue on this journey to explore the benefits of Hyperbaric Oxygen Therapy in Wound Care & other indications.